Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior

Factors underlying vulnerability to alcoholism are largely unknown. We identified an innate endophenotype in rodents that predicted individual risk for alcohol-related behaviors that was associated with decreased expression of the neuroplasticity-related cell-adhesion molecule PSA-NCAM. Depletion of...

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Detalles Bibliográficos
Autores principales: Barker, Jacqueline M., Torregrossa, Mary M., Taylor, Jane R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629946/
https://www.ncbi.nlm.nih.gov/pubmed/22922785
http://dx.doi.org/10.1038/nn.3194
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author Barker, Jacqueline M.
Torregrossa, Mary M.
Taylor, Jane R.
author_facet Barker, Jacqueline M.
Torregrossa, Mary M.
Taylor, Jane R.
author_sort Barker, Jacqueline M.
collection PubMed
description Factors underlying vulnerability to alcoholism are largely unknown. We identified an innate endophenotype in rodents that predicted individual risk for alcohol-related behaviors that was associated with decreased expression of the neuroplasticity-related cell-adhesion molecule PSA-NCAM. Depletion of PSA-NCAM within the ventromedial prefrontal cortex was sufficient to render mice unable to extinguish alcohol seeking, indicating a causal role of naturally occurring variation. These data demonstrate a novel mechanism of aberrant prefrontal neuroplasticity that underlies enhanced propensity for inflexible addiction-related behavior.
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spelling pubmed-36299462013-04-18 Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior Barker, Jacqueline M. Torregrossa, Mary M. Taylor, Jane R. Nat Neurosci Article Factors underlying vulnerability to alcoholism are largely unknown. We identified an innate endophenotype in rodents that predicted individual risk for alcohol-related behaviors that was associated with decreased expression of the neuroplasticity-related cell-adhesion molecule PSA-NCAM. Depletion of PSA-NCAM within the ventromedial prefrontal cortex was sufficient to render mice unable to extinguish alcohol seeking, indicating a causal role of naturally occurring variation. These data demonstrate a novel mechanism of aberrant prefrontal neuroplasticity that underlies enhanced propensity for inflexible addiction-related behavior. 2012-08-26 2012-10 /pmc/articles/PMC3629946/ /pubmed/22922785 http://dx.doi.org/10.1038/nn.3194 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Barker, Jacqueline M.
Torregrossa, Mary M.
Taylor, Jane R.
Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior
title Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior
title_full Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior
title_fullStr Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior
title_full_unstemmed Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior
title_short Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior
title_sort low prefrontal psa-ncam confers risk for alcoholism-related behavior
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629946/
https://www.ncbi.nlm.nih.gov/pubmed/22922785
http://dx.doi.org/10.1038/nn.3194
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