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Accelerated In Vivo Proliferation of Memory Phenotype CD4(+) T-cells in Human HIV-1 Infection Irrespective of Viral Chemokine Co-receptor Tropism

CD4(+) T-cell loss is the hallmark of HIV-1 infection. CD4 counts fall more rapidly in advanced disease when CCR5-tropic viral strains tend to be replaced by X4-tropic viruses. We hypothesized: (i) that the early dominance of CCR5-tropic viruses results from faster turnover rates of CCR5(+) cells, a...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, de Lara, Catherine, Worth, Andrew, Hegedus, Andrea, Laamanen, Karoliina, Beverley, Peter, Macallan, Derek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630096/
https://www.ncbi.nlm.nih.gov/pubmed/23637601
http://dx.doi.org/10.1371/journal.ppat.1003310