Pharmacokinetics and Interspecies Allometric Scaling of ST-246, an Oral Antiviral Therapeutic for Treatment of Orthopoxvirus Infection

Plasma pharmacokinetics of ST-246, smallpox therapeutic, was evaluated in mice, rabbits, monkeys and dogs following repeat oral administrations by gavage. The dog showed the lowest T(max) of 0.83 h and the monkey, the highest value of 3.25 h. A 2- to 4-fold greater dose-normalized C(max) was observe...

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Detalles Bibliográficos
Autores principales: Amantana, Adams, Chen, Yali, Tyavanagimatt, Shanthakumar R., Jones, Kevin F., Jordan, Robert, Chinsangaram, Jarasvech, Bolken, Tove′ C., Leeds, Janet M., Hruby, Dennis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630197/
https://www.ncbi.nlm.nih.gov/pubmed/23637845
http://dx.doi.org/10.1371/journal.pone.0061514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630197/
https://www.ncbi.nlm.nih.gov/pubmed/23637845
http://dx.doi.org/10.1371/journal.pone.0061514

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