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Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection
Autosomal recessive forms of Parkinson’s disease are caused by mutations in three genes: Parkin, PINK1, and DJ-1. These genes encode for proteins with distinct enzymatic activities that may work together to confer neuroprotection. Parkin is an E3 ubiquitin ligase that has been shown to ubiquitinate...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630392/ https://www.ncbi.nlm.nih.gov/pubmed/23626584 http://dx.doi.org/10.3389/fneur.2013.00038 |