Protease activation mutants elicit protective immunity against highly pathogenic avian influenza viruses of subtype H7 in chickens and mice

Protease activation mutants of the highly pathogenic avian influenza virus A/FPV/Rostock/34 (H7N1) have been generated that are fully dependent on the presence of trypsin for growth in cell culture. Unlike wild-type virus, the mutants do not induce systemic infection in chicken embryos and show low...

Descripción completa

Detalles Bibliográficos
Autores principales: Wagner, Ralf, Gabriel, Gülsah, Schlesner, Matthias, Alex, Nina, Herwig, Astrid, Werner, Ortrud, Klenk, Hans-Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630491/
https://www.ncbi.nlm.nih.gov/pubmed/26038453
http://dx.doi.org/10.1038/emi2013.7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630491/
https://www.ncbi.nlm.nih.gov/pubmed/26038453
http://dx.doi.org/10.1038/emi2013.7

Ejemplares similares