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Protease activation mutants elicit protective immunity against highly pathogenic avian influenza viruses of subtype H7 in chickens and mice

Protease activation mutants of the highly pathogenic avian influenza virus A/FPV/Rostock/34 (H7N1) have been generated that are fully dependent on the presence of trypsin for growth in cell culture. Unlike wild-type virus, the mutants do not induce systemic infection in chicken embryos and show low...

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Detalles Bibliográficos
Autores principales:	Wagner, Ralf, Gabriel, Gülsah, Schlesner, Matthias, Alex, Nina, Herwig, Astrid, Werner, Ortrud, Klenk, Hans-Dieter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630491/ https://www.ncbi.nlm.nih.gov/pubmed/26038453 http://dx.doi.org/10.1038/emi2013.7

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