Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic β cells

Pancreatic β cells respond to increases in glucose concentration with enhanced metabolism, the closure of ATP-sensitive K(+) channels and electrical spiking. The latter results in oscillatory Ca(2+) influx through voltage-gated Ca(2+) channels and the activation of insulin release. The relationship...

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Detalles Bibliográficos
Autores principales: Tarasov, Andrei I., Semplici, Francesca, Li, Daliang, Rizzuto, Rosario, Ravier, Magalie A., Gilon, Patrick, Rutter, Guy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Signaling and Cell Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631125/
https://www.ncbi.nlm.nih.gov/pubmed/23149488
http://dx.doi.org/10.1007/s00424-012-1177-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631125/
https://www.ncbi.nlm.nih.gov/pubmed/23149488
http://dx.doi.org/10.1007/s00424-012-1177-9

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