Supplementation of carnitine leads to an activation of the IGF-1/PI3K/Akt signalling pathway and down regulates the E3 ligase MuRF1 in skeletal muscle of rats

BACKGROUND: Recently, it has been shown that carnitine down-regulates genes involved in the ubiquitin-proteasome system (UPS) in muscle of pigs and rats. The mechanisms underlying this observation are yet unknown. Based on the previous finding that carnitine increases plasma IGF-1 concentration, we...

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Detalles Bibliográficos
Autores principales: Keller, Janine, Couturier, Aline, Haferkamp, Melanie, Most, Erika, Eder, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631133/
https://www.ncbi.nlm.nih.gov/pubmed/23497226
http://dx.doi.org/10.1186/1743-7075-10-28

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631133/
https://www.ncbi.nlm.nih.gov/pubmed/23497226
http://dx.doi.org/10.1186/1743-7075-10-28

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