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Supplementation of carnitine leads to an activation of the IGF-1/PI3K/Akt signalling pathway and down regulates the E3 ligase MuRF1 in skeletal muscle of rats

BACKGROUND: Recently, it has been shown that carnitine down-regulates genes involved in the ubiquitin-proteasome system (UPS) in muscle of pigs and rats. The mechanisms underlying this observation are yet unknown. Based on the previous finding that carnitine increases plasma IGF-1 concentration, we...

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Detalles Bibliográficos
Autores principales:	Keller, Janine, Couturier, Aline, Haferkamp, Melanie, Most, Erika, Eder, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631133/ https://www.ncbi.nlm.nih.gov/pubmed/23497226 http://dx.doi.org/10.1186/1743-7075-10-28

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