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Selective Activation of KCa3.1 and CRAC Channels by P(2)Y(2) Receptors Promotes Ca(2+) Signaling, Store Refilling and Migration of Rat Microglial Cells

Microglial activation involves Ca(2+) signaling, and numerous receptors can evoke elevation of intracellular Ca(2+). ATP released from damaged brain cells can activate ionotropic and metabotropic purinergic receptors, and act as a chemoattractant for microglia. Metabotropic P(2)Y receptors evoke a C...

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Detalles Bibliográficos
Autores principales: Ferreira, Roger, Schlichter, Lyanne C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631179/
https://www.ncbi.nlm.nih.gov/pubmed/23620825
http://dx.doi.org/10.1371/journal.pone.0062345