Structure of a Novel Shoulder-to-Shoulder p24 Dimer in Complex with the Broad-Spectrum Antibody A10F9 and Its Implication in Capsid Assembly

Mature HIV-1 viral particles assemble as a fullerene configuration comprising p24 capsid hexamers, pentamers and dimers. In this paper, we report the X-ray crystal structures of the p24 protein from natural HIV-1 strain (BMJ4) in complex with Fab A10F9, which recognizes a conserved epitope in the C-...

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Detalles Bibliográficos
Autores principales: Gu, Ying, Cao, Fang, Wang, Lei, Hou, Wangheng, Zhang, Jun, Hew, Choy-leong, Li, Shaowei, Yuan, Y. Adam, Xia, Ningshao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631186/
https://www.ncbi.nlm.nih.gov/pubmed/23620741
http://dx.doi.org/10.1371/journal.pone.0061314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631186/
https://www.ncbi.nlm.nih.gov/pubmed/23620741
http://dx.doi.org/10.1371/journal.pone.0061314

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