NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

Nicotinamide N-methyltransferase (NNMT) is overexpressed in a variety of human cancers, where it contributes to tumorigenesis by a still poorly understood mechanism. Here, we show using metabolomics that NNMT impairs the methylation potential of cancer cells by consuming methyl units from S-adenosyl...

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Detalles Bibliográficos
Autores principales: Ulanovskaya, Olesya A., Zuhl, Andrea M., Cravatt, Benjamin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631284/
https://www.ncbi.nlm.nih.gov/pubmed/23455543
http://dx.doi.org/10.1038/nchembio.1204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631284/
https://www.ncbi.nlm.nih.gov/pubmed/23455543
http://dx.doi.org/10.1038/nchembio.1204

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