Trypanosoma cruzi trans-sialidase initiates an ROR-γt–AHR-independent program leading to IL-17 production by activated B cells

We identified B cells as a major source for rapid, innate-like interleukin 17 (IL-17) production in vivo in response to Trypanosoma cruzi infection. IL-17(+) B cells exhibited a plasmablast phenotype, outnumbered T(H)17 cells and were required for optimal response to this pathogen. Using both murine...

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Detalles Bibliográficos
Autores principales: Bermejo, Daniela A, Jackson, Shaun W, Gorosito-Serran, Melisa, Acosta-Rodriguez, Eva V, Amezcua-Vesely, Maria C, Sather, Blythe D, Singh, Akhilesh K., Khim, Socheath, Mucci, Juan, Liggitt, Denny, Campetella, Oscar, Oukka, Mohamed, Gruppi, Adriana, Rawlings, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631452/
https://www.ncbi.nlm.nih.gov/pubmed/23563688
http://dx.doi.org/10.1038/ni.2569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631452/
https://www.ncbi.nlm.nih.gov/pubmed/23563688
http://dx.doi.org/10.1038/ni.2569

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