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Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection
NOD2 receptor and the cytosolic protein kinase RIPK2 regulate NF-κB and MAP kinase signaling during bacterial infections, but the role of this immune axis during viral infections has not been addressed. We demonstrate that Nod2(−/−) and Ripk2(−/−) mice are hypersusceptible to influenza A virus infec...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631456/ https://www.ncbi.nlm.nih.gov/pubmed/23525089 http://dx.doi.org/10.1038/ni.2563 |