Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection

NOD2 receptor and the cytosolic protein kinase RIPK2 regulate NF-κB and MAP kinase signaling during bacterial infections, but the role of this immune axis during viral infections has not been addressed. We demonstrate that Nod2(−/−) and Ripk2(−/−) mice are hypersusceptible to influenza A virus infec...

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Detalles Bibliográficos
Autores principales: Lupfer, Christopher, Thomas, Paul G., Anand, Paras K., Vogel, Peter, Milasta, Sandra, Martinez, Jennifer, Huang, Gonghua, Green, Maggie, Kundu, Mondira, Chi, Hongbo, Xavier, Ramnik J., Green, Douglas R., Lamkanfi, Mohamed, Dinarello, Charles A., Doherty, Peter C., Kanneganti, Thirumala-Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631456/
https://www.ncbi.nlm.nih.gov/pubmed/23525089
http://dx.doi.org/10.1038/ni.2563

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