Dual fluorescent molecular substrates selectively report the activation, sustainability and reversibility of cellular PKB/Akt activity

Using a newly developed near-infrared (NIR) dye that fluoresces at two different wavelengths (dichromic fluorescence, DCF), we discovered a new fluorescent substrate for Akt, also known as protein kinase B, and a method to quantitatively report this enzyme's activity in real time. Upon insulin...

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Detalles Bibliográficos
Autores principales: Shen, Duanwen, Bai, Mingfeng, Tang, Rui, Xu, Baogang, Ju, Xiaoming, Pestell, Richard G., Achilefu, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631771/
https://www.ncbi.nlm.nih.gov/pubmed/23603888
http://dx.doi.org/10.1038/srep01697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631771/
https://www.ncbi.nlm.nih.gov/pubmed/23603888
http://dx.doi.org/10.1038/srep01697

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