Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis

Asp(443) and Glu(478) are essential active site residues in the RNase H domain of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). We have investigated the effects of substituting Asn for Asp(443) or Gln for Glu(478) on the fidelity of DNA-dependent DNA synthesis of phylogenet...

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Detalles Bibliográficos
Autores principales: Álvarez, Mar, Barrioluengo, Verónica, Afonso-Lehmann, Raquel N., Menéndez-Arias, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632107/
https://www.ncbi.nlm.nih.gov/pubmed/23444139
http://dx.doi.org/10.1093/nar/gkt109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632107/
https://www.ncbi.nlm.nih.gov/pubmed/23444139
http://dx.doi.org/10.1093/nar/gkt109

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