Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance

Although quinolones are the most commonly prescribed antibacterials, their use is threatened by an increasing prevalence of resistance. The most common causes of quinolone resistance are mutations of a specific serine or acidic residue in the A subunit of gyrase or topoisomerase IV. These amino acid...

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Detalles Bibliográficos
Autores principales: Aldred, Katie J., McPherson, Sylvia A., Turnbough, Charles L., Kerns, Robert J., Osheroff, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632122/
https://www.ncbi.nlm.nih.gov/pubmed/23460203
http://dx.doi.org/10.1093/nar/gkt124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632122/
https://www.ncbi.nlm.nih.gov/pubmed/23460203
http://dx.doi.org/10.1093/nar/gkt124

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