Neonatal Disruption of Serine Racemase Causes Schizophrenia-Like Behavioral Abnormalities in Adulthood: Clinical Rescue by D-Serine

BACKGROUND: D-Serine, an endogenous co-agonist of the N-methyl-D-aspartate (NMDA) receptor, is synthesized from L-serine by serine racemase (SRR). Given the role of D-serine in both neurodevelopment and the pathophysiology of schizophrenia, we examined whether neonatal disruption of D-serine synthes...

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Detalles Bibliográficos
Autores principales: Hagiwara, Hiroko, Iyo, Masaomi, Hashimoto, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632541/
https://www.ncbi.nlm.nih.gov/pubmed/23630632
http://dx.doi.org/10.1371/journal.pone.0062438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632541/
https://www.ncbi.nlm.nih.gov/pubmed/23630632
http://dx.doi.org/10.1371/journal.pone.0062438

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