Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain

To assess the role of the kynurenine pathway in the pathology of Alzheimer's disease (AD), the expression and localization of key components of the kynurenine pathway including the key regulatory enzyme tryptophan 2,3 dioxygenase (TDO), and the metabolites tryptophan, kynurenine, kynurenic acid...

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Detalles Bibliográficos
Autores principales: Wu, Wei, Nicolazzo, Joseph A., Wen, Li, Chung, Roger, Stankovic, Roger, Bao, Shisan S., Lim, Chai K., Brew, Bruce J., Cullen, Karen M., Guillemin, Gilles J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632609/
https://www.ncbi.nlm.nih.gov/pubmed/23630570
http://dx.doi.org/10.1371/journal.pone.0059749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632609/
https://www.ncbi.nlm.nih.gov/pubmed/23630570
http://dx.doi.org/10.1371/journal.pone.0059749

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