Cargando…

Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain

To assess the role of the kynurenine pathway in the pathology of Alzheimer's disease (AD), the expression and localization of key components of the kynurenine pathway including the key regulatory enzyme tryptophan 2,3 dioxygenase (TDO), and the metabolites tryptophan, kynurenine, kynurenic acid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Wei, Nicolazzo, Joseph A., Wen, Li, Chung, Roger, Stankovic, Roger, Bao, Shisan S., Lim, Chai K., Brew, Bruce J., Cullen, Karen M., Guillemin, Gilles J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632609/ https://www.ncbi.nlm.nih.gov/pubmed/23630570 http://dx.doi.org/10.1371/journal.pone.0059749

Ejemplares similares

The Plasma [Kynurenine]/[Tryptophan] Ratio and Indoleamine 2,3-Dioxygenase: Time for Appraisal
por: Badawy, Abdulla A-B, et al.
Publicado: (2019)

Kynurenine Is the Main Metabolite of Tryptophan Degradation by Tryptophan 2,3-Dioxygenase in HepG2 Tumor Cells
por: Oweira, Hani, et al.
Publicado: (2022)

The Relationships among Tryptophan, Kynurenine, Indoleamine 2,3-Dioxygenase, Depression, and Neuropsychological Performance
por: Hestad, Knut A., et al.
Publicado: (2017)

Enhanced tryptophan-kynurenine metabolism via indoleamine 2,3-dioxygenase 1 induction in dermatomyositis
por: Wu, Dan, et al.
Publicado: (2022)

Correction to: Enhanced tryptophan-kynurenine metabolism via indoleamine 2,3-dioxygenase 1 induction in dermatomyositis
por: Wu, Dan, et al.
Publicado: (2022)

Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis
por: Lovelace, Michael D., et al.
Publicado: (2016)

The Effect of Tryptophan 2,3-Dioxygenase Inhibition on Kynurenine Metabolism and Cognitive Function in the APP23 Mouse Model of Alzheimer’s Disease
por: Sorgdrager, FJH, et al.
Publicado: (2020)

Indoleamine 2,3‐dioxygenase gene expression and kynurenine to tryptophan ratio correlation with nasopharyngeal carcinoma progression and survival
por: Souissi, Sameh, et al.
Publicado: (2022)

Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans
por: Valente-Silva, Paula, et al.
Publicado: (2021)

Correction: Oweira et al. Kynurenine Is the Main Metabolite of Tryptophan Degradation by Tryptophan 2,3-Dioxygenase in HepaRG Tumor Cells. J. Clin. Med. 2022, 11, 4794
por: Oweira, Hani, et al.
Publicado: (2023)

Indoleamine-2,3-Dioxygenase Mediates Emotional Deficits by the Kynurenine/Tryptophan Pathway in the Ethanol Addiction/Withdrawal Mouse Model
por: Jiang, Xi, et al.
Publicado: (2020)

Exploring the mechanism of tryptophan 2,3-dioxygenase
por: Thackray, Sarah J., et al.
Publicado: (2008)

Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model
por: Jiang, Xi, et al.
Publicado: (2018)

Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma
por: Terai, Mizue, et al.
Publicado: (2020)

Understanding the Roles of the Kynurenine Pathway in Multiple Sclerosis Progression
por: Lim, Chai K., et al.
Publicado: (2010)

Editorial: Targeting Indoleamine 2,3-dioxygenases and Tryptophan Dioxygenase for Cancer Immunotherapy
por: Brochez, Lieve, et al.
Publicado: (2021)

Association of Microbial Tryptophan Metabolites and Indoleamine-2,3-Dioxygenase with Immune Activity in Healthy Adults
por: Riazati, Niknaz, et al.
Publicado: (2022)

The Kynurenine Pathway in Stem Cell Biology
por: Jones, Simon P., et al.
Publicado: (2013)

Peripheral kynurenine/tryptophan ratio is not a reliable marker of systemic indoleamine 2,3-dioxygenase: A lesson drawn from patients on hemodialysis
por: Chen, Yuanhan, et al.
Publicado: (2017)

Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites
por: Yan, Jingya, et al.
Publicado: (2022)

Tryptophan Metabolism in Rat Liver After Administration of Tryptophan, Kynurenine Metabolites, and Kynureninase Inhibitors
por: Badawy, Abdulla A.-B., et al.
Publicado: (2016)

A narrative review of the roles of indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in liver diseases
por: Zhou, Qihui, et al.
Publicado: (2021)

The impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites
por: Yeung, Kai Tai Derek, et al.
Publicado: (2022)

Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression
por: Sundaram, Gayathri, et al.
Publicado: (2020)

Associations of microbial and indoleamine-2,3-dioxygenase-derived tryptophan metabolites with immune activation in healthy adults
por: Riazati, Niknaz, et al.
Publicado: (2022)

Effects of Kynurenine Pathway Metabolites on Intracellular NAD(+) Synthesis and Cell Death in Human Primary Astrocytes and Neurons
por: Braidy, Nady, et al.
Publicado: (2009)

Negative Impact of Hypoxia on Tryptophan 2,3-Dioxygenase Function
por: Elbers, Frank, et al.
Publicado: (2016)

Kynurenine Pathway Metabolites in Humans: Disease and Healthy States
por: Chen, Yiquan, et al.
Publicado: (2009)

Interleukin‐6 promotes skeletal muscle catabolism by activating tryptophan–indoleamine 2,3‐dioxygenase 1–kynurenine pathway during intra‐abdominal sepsis
por: Xie, Tingbin, et al.
Publicado: (2023)

Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase
por: Yoshioka, Saeko, et al.
Publicado: (2022)

Tryptophan-Restriction Diets Help to Maintain L-Tryptophan Homeostasis in Tryptophan 2,3-Dioxygenase Knockout Mice
por: Maeta, Akihiro, et al.
Publicado: (2013)

Kynurenine Pathway Metabolites as Biomarkers for Amyotrophic Lateral Sclerosis
por: Tan, Vanessa X., et al.
Publicado: (2019)

Influence of Indoleamine-2,3-Dioxygenase and Its Metabolite Kynurenine on γδ T Cell Cytotoxicity against Ductal Pancreatic Adenocarcinoma Cells
por: Jonescheit, Hannah, et al.
Publicado: (2020)

Function of the tryptophan metabolite, L-kynurenine, in human corneal endothelial cells
por: Serbecic, Nermin, et al.
Publicado: (2009)

Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway
por: Tanaka, Masaru, et al.
Publicado: (2021)

Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer
por: Chen, I-Chien, et al.
Publicado: (2016)

Influence of Tryptophan Contained in 1-Methyl-Tryptophan on Antimicrobial and Immunoregulatory Functions of Indoleamine 2,3-Dioxygenase
por: Schmidt, Silvia K., et al.
Publicado: (2012)

Inhibition of Allogeneic T Cell Proliferation by Indoleamine 2,3-Dioxygenase–expressing Dendritic Cells: Mediation of Suppression by Tryptophan Metabolites
por: Terness, Peter, et al.
Publicado: (2002)

Microorganisms, Tryptophan Metabolism, and Kynurenine Pathway: A Complex Interconnected Loop Influencing Human Health Status
por: Dehhaghi, Mona, et al.
Publicado: (2019)

An Expanded Neuroimmunomodulation Axis: sCD83-Indoleamine 2,3-Dioxygenase—Kynurenine Pathway and Updates of Kynurenine Pathway in Neurologic Diseases
por: Bo, Li, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_kjn5iao8vjco7fnoa3t9cq9fcu