Properdin and Factor H: Opposing Players on the Alternative Complement Pathway “See-Saw”

Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilizing the C3bBb complex, whereas factor H downregulates the pathway by promoting proteolytic degradation of C3b. While facto...

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Detalles Bibliográficos
Autores principales: Kouser, Lubna, Abdul-Aziz, Munirah, Nayak, Annapurna, Stover, Cordula M., Sim, Robert B., Kishore, Uday
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632793/
https://www.ncbi.nlm.nih.gov/pubmed/23630525
http://dx.doi.org/10.3389/fimmu.2013.00093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632793/
https://www.ncbi.nlm.nih.gov/pubmed/23630525
http://dx.doi.org/10.3389/fimmu.2013.00093

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