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Properdin and Factor H: Opposing Players on the Alternative Complement Pathway “See-Saw”
Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway. Properdin up-regulates the alternative pathway by stabilizing the C3bBb complex, whereas factor H downregulates the pathway by promoting proteolytic degradation of C3b. While facto...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632793/ https://www.ncbi.nlm.nih.gov/pubmed/23630525 http://dx.doi.org/10.3389/fimmu.2013.00093 |