DNA replication timing and higher-order nuclear organization determine single nucleotide substitution patterns in cancer genomes

Single nucleotide substitutions (SNS) are a defining characteristic of cancer genomes. Many SNS in cancer genomes arise due to errors in DNA replication, which is spatio-temporally stratified. Here we propose that DNA replication patterns help shape the mutational landscapes of normal and cancer gen...

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Detalles Bibliográficos
Autores principales: Liu, Lin, De, Subhajyoti, Michor, Franziska
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633418/
https://www.ncbi.nlm.nih.gov/pubmed/23422670
http://dx.doi.org/10.1038/ncomms2502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633418/
https://www.ncbi.nlm.nih.gov/pubmed/23422670
http://dx.doi.org/10.1038/ncomms2502

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