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DNA replication timing and higher-order nuclear organization determine single nucleotide substitution patterns in cancer genomes
Single nucleotide substitutions (SNS) are a defining characteristic of cancer genomes. Many SNS in cancer genomes arise due to errors in DNA replication, which is spatio-temporally stratified. Here we propose that DNA replication patterns help shape the mutational landscapes of normal and cancer gen...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633418/ https://www.ncbi.nlm.nih.gov/pubmed/23422670 http://dx.doi.org/10.1038/ncomms2502 |