Mouse Transplant Models for Evaluating the Oncogenic Risk of a Self-Inactivating XSCID Lentiviral Vector

Hematopoietic stem cell gene therapy requires the use of integrating retroviral vectors in order to stably transmit a therapeutic gene to mature blood cells. Human clinical trials have shown that some vector integration events lead to disrupted regulation of proto-oncogenes resulting in disordered h...

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Detalles Bibliográficos
Autores principales: Zhou, Sheng, Ma, Zhijun, Lu, Taihe, Janke, Laura, Gray, John T., Sorrentino, Brian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633865/
https://www.ncbi.nlm.nih.gov/pubmed/23626802
http://dx.doi.org/10.1371/journal.pone.0062333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633865/
https://www.ncbi.nlm.nih.gov/pubmed/23626802
http://dx.doi.org/10.1371/journal.pone.0062333

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