ATM Influences the Efficiency of TCRβ Rearrangement, Subsequent TCRβ-Dependent T Cell Development, and Generation of the Pre-Selection TCRβ CDR3 Repertoire

Generation and resolution of DNA double-strand breaks is required to assemble antigen-specific receptors from the genes encoding V, D, and J gene segments during recombination. The present report investigates the requirement for ataxia telangiectasia-mutated (ATM) kinase, a component of DNA double-s...

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Detalles Bibliográficos
Autores principales: Hathcock, Karen S., Bowen, Steven, Livak, Ferenc, Hodes, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633875/
https://www.ncbi.nlm.nih.gov/pubmed/23626787
http://dx.doi.org/10.1371/journal.pone.0062188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633875/
https://www.ncbi.nlm.nih.gov/pubmed/23626787
http://dx.doi.org/10.1371/journal.pone.0062188

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