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LC-MS/MS Determination of Isoprostanes in Plasma Samples Collected from Mice Exposed to Doxorubicin or Tert-Butyl Hydroperoxide

Isoprostanes are stable products of arachidonic acid peroxidation and are regarded as the most reliable markers of oxidative stress in vivo. Here we describe the LC-MS/MS procedure enabling simultaneous determination of four regioisomers (8-iso prostaglandin F(2α), 8-iso-15(R)-prostaglandin F(2α), 1...

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Detalles Bibliográficos
Autores principales: Janicka, Monika, Kot-Wasik, Agata, Paradziej-Łukowicz, Jolanta, Sularz-Peszyńska, Grażyna, Bartoszek, Agnieszka, Namieśnik, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634494/
https://www.ncbi.nlm.nih.gov/pubmed/23507752
http://dx.doi.org/10.3390/ijms14036157