Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium

The C subunit of the vacuolar H(+)-ATPase or V-ATPase regulates the activity and assembly of the proton pump at cellular membranes. It has been shown to be strongly upregulated in oral squamous cell carcinoma, a highly metastatic epithelial cancer. In addition, increased V-ATPase activity appears to...

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Detalles Bibliográficos
Autores principales: Petzoldt, Astrid G., Gleixner, Eva Maria, Fumagalli, Arianna, Vaccari, Thomas, Simons, Matias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634652/
https://www.ncbi.nlm.nih.gov/pubmed/23335205
http://dx.doi.org/10.1242/dmm.010660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634652/
https://www.ncbi.nlm.nih.gov/pubmed/23335205
http://dx.doi.org/10.1242/dmm.010660

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