An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias

PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. The role of PTEN in carcinogenesis has been validated by knockout mouse models. PTEN heterozygous mice develop neoplasms in multiple organs. Unfortunately, the embryonic lethality of biallelic excision of PTEN has in...

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Detalles Bibliográficos
Autores principales: Mirantes, Cristina, Eritja, Núria, Dosil, Maria Alba, Santacana, Maria, Pallares, Judit, Gatius, Sónia, Bergadà, Laura, Maiques, Oscar, Matias-Guiu, Xavier, Dolcet, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634654/
https://www.ncbi.nlm.nih.gov/pubmed/23471917
http://dx.doi.org/10.1242/dmm.011445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634654/
https://www.ncbi.nlm.nih.gov/pubmed/23471917
http://dx.doi.org/10.1242/dmm.011445

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