A murine Zic3 transcript with a premature termination codon evades nonsense-mediated decay during axis formation

The ZIC transcription factors are key mediators of embryonic development and ZIC3 is the gene most commonly associated with situs defects (heterotaxy) in humans. Half of patient ZIC3 mutations introduce a premature termination codon (PTC). In vivo, PTC-containing transcripts might be targeted for no...

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Detalles Bibliográficos
Autores principales: Ahmed, Jehangir N., Ali, Radiya G., Warr, Nicholas, Wilson, Heather M., Bellchambers, Helen M., Barratt, Kristen S., Thompson, Amelia J., Arkell, Ruth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634658/
https://www.ncbi.nlm.nih.gov/pubmed/23471918
http://dx.doi.org/10.1242/dmm.011668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634658/
https://www.ncbi.nlm.nih.gov/pubmed/23471918
http://dx.doi.org/10.1242/dmm.011668

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