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Chemical Chaperones Exceed the Chaperone Effects of RIC-3 in Promoting Assembly of Functional α7 AChRs

Functional α7 nicotinic acetylcholine receptors (AChRs) do not assemble efficiently in cells transfected with α7 subunits unless the cells are also transfected with the chaperone protein RIC-3. Despite the presence of RIC-3, large amounts of these subunits remain improperly assembled. Thus, addition...

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Detalles Bibliográficos
Autores principales: Kuryatov, Alexander, Mukherjee, Jayanta, Lindstrom, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634732/
https://www.ncbi.nlm.nih.gov/pubmed/23638015
http://dx.doi.org/10.1371/journal.pone.0062246