Antibody to Ricin A Chain Hinders Intracellular Routing of Toxin and Protects Cells Even after Toxin Has Been Internalized

BACKGROUND: Mechanisms of antibody-mediated neutralization are of much interest. For plant and bacterial A-B toxins, A chain mediates toxicity and B chain binds target cells. It is generally accepted and taught that antibody (Ab) neutralizes by preventing toxin binding to cells. Yet for some toxins,...

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Detalles Bibliográficos
Autores principales: Song, Kejing, Mize, R. Ranney, Marrero, Luis, Corti, Miriam, Kirk, Jason M., Pincus, Seth H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634765/
https://www.ncbi.nlm.nih.gov/pubmed/23638075
http://dx.doi.org/10.1371/journal.pone.0062417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634765/
https://www.ncbi.nlm.nih.gov/pubmed/23638075
http://dx.doi.org/10.1371/journal.pone.0062417

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