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Conserved N-Terminal Negative Charges Support Optimally Efficient N-type Inactivation of Kv1 Channels

N-type inactivation is produced by the binding of a potassium channel's N-terminus within the open pore, blocking conductance. Previous studies have found that introduction of negative charges into N-terminal inactivation domains disrupts inactivation; however, the Aplysia AKv1 N-type inactivat...

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Detalles Bibliográficos
Autores principales: Prince, Alison, Pfaffinger, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634772/
https://www.ncbi.nlm.nih.gov/pubmed/23638135
http://dx.doi.org/10.1371/journal.pone.0062695

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