Cargando…

Microarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated Modulation of LPS-Induced Activation of BV-2 Microglial Cells

Cannabinoids are known to exert immunosuppressive activities. However, the mechanisms which contribute to these effects are unknown. Using lipopolysaccharide (LPS) to activate BV-2 microglial cells, we examined how Δ(9)-tetrahydrocannabinol (THC), the major psychoactive component of marijuana, and c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Juknat, Ana, Pietr, Maciej, Kozela, Ewa, Rimmerman, Neta, Levy, Rivka, Gao, Fuying, Coppola, Giovanni, Geschwind, Daniel, Vogel, Zvi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634783/ https://www.ncbi.nlm.nih.gov/pubmed/23637839 http://dx.doi.org/10.1371/journal.pone.0061462

Ejemplares similares

miRNA expression profiles and molecular networks in resting and LPS-activated BV-2 microglia—Effect of cannabinoids
por: Juknat, Ana, et al.
Publicado: (2019)

Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells
por: Kozela, Ewa, et al.
Publicado: (2016)

Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid
por: Kozela, Ewa, et al.
Publicado: (2017)

Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells
por: Kozela, Ewa, et al.
Publicado: (2015)

Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death
por: Rimmerman, N, et al.
Publicado: (2013)

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor
por: McHugh, Douglas, et al.
Publicado: (2010)

PACAP and VIP Modulate LPS-Induced Microglial Activation and Trigger Distinct Phenotypic Changes in Murine BV2 Microglial Cells
por: Karunia, Jocelyn, et al.
Publicado: (2021)

Effects of ginsenoside Re on LPS-induced inflammatory mediators in BV2 microglial cells
por: Lee, Kang-Woo, et al.
Publicado: (2012)

Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice
por: Nam, Hye Yeon, et al.
Publicado: (2018)

Scoparone Inhibits LPS-Simulated Inflammatory Response by Suppressing IRF3 and ERK in BV-2 Microglial Cells
por: Cho, Duk-Yeon, et al.
Publicado: (2016)

LPS-Induced proNGF Synthesis and Release in the N9 and BV2 Microglial Cells: A New Pathway Underling Microglial Toxicity in Neuroinflammation
por: Duan, Li, et al.
Publicado: (2013)

RNA sequencing reveals distinct mechanisms underlying BET inhibitor JQ1-mediated modulation of the LPS-induced activation of BV-2 microglial cells
por: Jung, Kyoung Hwa, et al.
Publicado: (2015)

Salidroside Reduces Cell Mobility via NF-κB and MAPK Signaling in LPS-Induced BV2 Microglial Cells
por: Hu, Haixia, et al.
Publicado: (2014)

Hypoxia potentiates cytotoxicity of LPS-activated microglial BV2 cells in vitro by synergistic effects on cytokine and nitric oxide secretion
por: Jung, Susan, et al.
Publicado: (2015)

Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson’s Disease Mice
por: Yan, Aijuan, et al.
Publicado: (2019)

Hispidin inhibits LPS-induced nitric oxide production in BV-2 microglial cells via ROS-dependent MAPK signaling
por: Jin, Mei-Hua, et al.
Publicado: (2021)

Tryptanthrin Suppresses the Activation of the LPS-Treated BV2 Microglial Cell Line via Nrf2/HO-1 Antioxidant Signaling
por: Kwon, Young-Won, et al.
Publicado: (2017)

Involvement of NFƙB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS
por: Hilliard, Aaron, et al.
Publicado: (2020)

Osteogenic growth peptide is a potent anti-inflammatory and bone preserving hormone via cannabinoid receptor type 2
por: Raphael-Mizrahi, Bitya, et al.
Publicado: (2022)

Pharmacological blockade of cannabinoid receptor 2 signaling does not affect LPS/IFN-γ-induced microglial activation
por: Olabiyi, Bolanle Fatimat, et al.
Publicado: (2023)

Phyllanthus amarus prevents LPS-mediated BV2 microglial activation via MyD88 and NF-κB signaling pathways
por: Ismail, Elysha Nur, et al.
Publicado: (2020)

Effects of α-lipoic acid on LPS-induced neuroinflammation and NLRP3 inflammasome activation through the regulation of BV-2 microglial cells activation
por: Kim, Su Min, et al.
Publicado: (2019)

Suppression of LPS-Induced Inflammation and Cell Migration by Azelastine through Inhibition of JNK/NF-κB Pathway in BV2 Microglial Cells
por: Nguyen, Phuong Linh, et al.
Publicado: (2021)

Trimethyltin-Induced Microglial Activation via NADPH Oxidase and MAPKs Pathway in BV-2 Microglial Cells
por: Kim, Da Jung, et al.
Publicado: (2015)

Investigations into the Role of Metabolism in the Inflammatory Response of BV2 Microglial Cells
por: Maher, Pamela
Publicado: (2021)

The TSPO Ligands 2-Cl-MGV-1, MGV-1, and PK11195 Differentially Suppress the Inflammatory Response of BV-2 Microglial Cell to LPS
por: Azrad, Maya, et al.
Publicado: (2019)

Autophagy down regulates pro-inflammatory mediators in BV2 microglial cells and rescues both LPS and alpha-synuclein induced neuronal cell death
por: Bussi, Claudio, et al.
Publicado: (2017)

Antineuroinflammatory Effect of Amburana cearensis and Its Molecules Coumarin and Amburoside A by Inhibiting the MAPK Signaling Pathway in LPS-Activated BV-2 Microglial Cells
por: de Araújo, Ana Bruna, et al.
Publicado: (2022)

Assessing the Anti-Inflammatory Activity of the Anxiolytic Drug Buspirone Using CRISPR-Cas9 Gene Editing in LPS-Stimulated BV-2 Microglial Cells
por: Thomas Broome, Sarah, et al.
Publicado: (2021)

Antioxidant and Anti-Inflammatory Mechanisms of Cardamonin through Nrf2 Activation and NF-kB Suppression in LPS-Activated BV-2 Microglial Cells
por: Barber, Kimberly, et al.
Publicado: (2023)

Author Correction: Pharmacological blockade of cannabinoid receptor 2 signaling does not affect LPS/IFN-γ-induced microglial activation
por: Olabiyi, Bolanle Fatimat, et al.
Publicado: (2023)

Benfotiamine Attenuates Inflammatory Response in LPS Stimulated BV-2 Microglia
por: Bozic, Iva, et al.
Publicado: (2015)

3,4,5-Trihydroxycinnamic Acid Inhibits LPS-Induced iNOS Expression by Suppressing NF-κB Activation in BV2 Microglial Cells
por: Lee, Jae-Won, et al.
Publicado: (2012)

Royal Jelly Attenuates LPS-Induced Inflammation in BV-2 Microglial Cells through Modulating NF-κB and p38/JNK Signaling Pathways
por: You, Meng-Meng, et al.
Publicado: (2018)

Anti-inflammatory effects of spermidine in lipopolysaccharide-stimulated BV2 microglial cells
por: Choi, Yung Hyun, et al.
Publicado: (2012)

Cell damage produced by magnetic fluid hyperthermia on microglial BV2 cells
por: Calatayud, M. Pilar, et al.
Publicado: (2017)

Effect of Glycine on BV-2 Microglial Cells Treated with Interferon-γ and Lipopolysaccharide
por: Egger, Florentina, et al.
Publicado: (2020)

Effects of Haloperidol, Risperidone, and Aripiprazole on the Immunometabolic Properties of BV-2 Microglial Cells
por: Racki, Valentino, et al.
Publicado: (2021)

PACAP and VIP Mitigate Rotenone-Induced Inflammation in BV-2 Microglial Cells
por: Broome, Sarah Thomas, et al.
Publicado: (2022)

Necrotic-like BV-2 microglial cell death due to methylmercury exposure
por: Martins, B., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_v0ukb3snkh5580ltbc1as3jr8o