Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development

BACKGROUND: Inhalation of endotoxin (LPS) induces a predominantly neutrophilic airway inflammation and has been used as model to test the anti-inflammatory activity of novel drugs. In the past, a dose exceeding 15–50 μg was generally needed to induce a sufficient inflammatory response. For human stu...

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Detalles Bibliográficos
Autores principales: Janssen, Ole, Schaumann, Frank, Holz, Olaf, Lavae-Mokhtari, Bianca, Welker, Lutz, Winkler, Carla, Biller, Heike, Krug, Norbert, Hohlfeld, Jens M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635929/
https://www.ncbi.nlm.nih.gov/pubmed/23537365
http://dx.doi.org/10.1186/1471-2466-13-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635929/
https://www.ncbi.nlm.nih.gov/pubmed/23537365
http://dx.doi.org/10.1186/1471-2466-13-19

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