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Low-dose endotoxin inhalation in healthy volunteers - a challenge model for early clinical drug development
BACKGROUND: Inhalation of endotoxin (LPS) induces a predominantly neutrophilic airway inflammation and has been used as model to test the anti-inflammatory activity of novel drugs. In the past, a dose exceeding 15–50 μg was generally needed to induce a sufficient inflammatory response. For human stu...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635929/ https://www.ncbi.nlm.nih.gov/pubmed/23537365 http://dx.doi.org/10.1186/1471-2466-13-19 |