PRIMA-1 increases cisplatin sensitivity in chemoresistant ovarian cancer cells with p53 mutation: a requirement for Akt down-regulation

BACKGROUND: Since ovarian cancer is associated with high frequency of p53 mutation, the availability of p53 reactivation and induction of massive apoptosis (PRIMA-1) offers a possible new therapeutic strategy for overcoming this devastating disease. Although Akt activation is believed to be a determ...

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Detalles Bibliográficos
Autores principales: Kobayashi, Noriko, Abedini, Mohammadreza, Sakuragi, Noriaki, Tsang, Benjamin K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636020/
https://www.ncbi.nlm.nih.gov/pubmed/23351152
http://dx.doi.org/10.1186/1757-2215-6-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636020/
https://www.ncbi.nlm.nih.gov/pubmed/23351152
http://dx.doi.org/10.1186/1757-2215-6-7

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