Complex Structure of OspI and Ubc13: The Molecular Basis of Ubc13 Deamidation and Convergence of Bacterial and Host E2 Recognition

Ubc13 is an important ubiquitin-conjugating (E2) enzyme in the NF-κB signaling pathway. The Shigella effector OspI targets Ubc13 and deamidates Gln100 of Ubc13 to a glutamic acid residue, leading to the inhibition of host inflammatory responses. Here we report the crystal structure of the OspI-Ubc13...

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Detalles Bibliográficos
Autores principales: Fu, Panhan, Zhang, Xiaoqing, Jin, Mengmeng, Xu, Li, Wang, Chong, Xia, Zongping, Zhu, Yongqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636029/
https://www.ncbi.nlm.nih.gov/pubmed/23633953
http://dx.doi.org/10.1371/journal.ppat.1003322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636029/
https://www.ncbi.nlm.nih.gov/pubmed/23633953
http://dx.doi.org/10.1371/journal.ppat.1003322

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