Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants

The PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase, and pink1 mutations cause early onset Parkinson's disease (PD) in humans. Loss of pink1 in Drosophila leads to defects in mitochondrial function, and genetic data suggest that another PD-related gene product, Parkin, acts with pink1 t...

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Detalles Bibliográficos
Autores principales: Esposito, Giovanni, Vos, Melissa, Vilain, Sven, Swerts, Jef, De Sousa Valadas, Jorge, Van Meensel, Stefanie, Schaap, Onno, Verstreken, Patrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636082/
https://www.ncbi.nlm.nih.gov/pubmed/23637640
http://dx.doi.org/10.1371/journal.pgen.1003478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636082/
https://www.ncbi.nlm.nih.gov/pubmed/23637640
http://dx.doi.org/10.1371/journal.pgen.1003478

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