Cargando…

Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants

The PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase, and pink1 mutations cause early onset Parkinson's disease (PD) in humans. Loss of pink1 in Drosophila leads to defects in mitochondrial function, and genetic data suggest that another PD-related gene product, Parkin, acts with pink1 t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Esposito, Giovanni, Vos, Melissa, Vilain, Sven, Swerts, Jef, De Sousa Valadas, Jorge, Van Meensel, Stefanie, Schaap, Onno, Verstreken, Patrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636082/ https://www.ncbi.nlm.nih.gov/pubmed/23637640 http://dx.doi.org/10.1371/journal.pgen.1003478

Ejemplares similares

The Yeast Complex I Equivalent NADH Dehydrogenase Rescues pink1 Mutants
por: Vilain, Sven, et al.
Publicado: (2012)

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila
por: Cornelissen, Tom, et al.
Publicado: (2018)

Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency
por: Vos, Melissa, et al.
Publicado: (2017)

Dynamin photoinactivation blocks Clathrin and α-adaptin recruitment and induces bulk membrane retrieval
por: Kasprowicz, Jaroslaw, et al.
Publicado: (2014)

Mitochondrial DNA Instability in Cells Lacking Aconitase Correlates with Iron Citrate Toxicity
por: Farooq, Muhammad A., et al.
Publicado: (2013)

Neuronal identity defines α-synuclein and tau toxicity
por: Praschberger, Roman, et al.
Publicado: (2023)

The Iron Maiden. Cytosolic Aconitase/IRP1 Conformational Transition in the Regulation of Ferritin Translation and Iron Hemostasis
por: Hognon, Cécilia, et al.
Publicado: (2021)

Torsin and NEP1R1‐CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid‐dependent and lipid‐independent mechanisms
por: Jacquemyn, Julie, et al.
Publicado: (2021)

Aconitase: To Be or not to Be Inside Plant Glyoxysomes, That Is the Question
por: De Bellis, Luigi, et al.
Publicado: (2020)

Crystal structures of aconitase X enzymes from bacteria and archaea provide insights into the molecular evolution of the aconitase superfamily
por: Watanabe, Seiya, et al.
Publicado: (2021)

Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants
por: Klein, Pontus, et al.
Publicado: (2014)

Fast and Efficient Drosophila melanogaster Gene Knock-Ins Using MiMIC Transposons
por: Vilain, Sven, et al.
Publicado: (2014)

Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration
por: Fernandes, Ana Clara, et al.
Publicado: (2014)

Mitochondrial Aconitase ACO2 Links Iron Homeostasis with Tumorigenicity in Non–Small Cell Lung Cancer
por: Mirhadi, Shideh, et al.
Publicado: (2023)

Deferiprone targets aconitase: Implication for Friedreich's ataxia treatment
por: Goncalves, Sergio, et al.
Publicado: (2008)

Inactivation of Aconitase by Tetrahydrobiopterin in DArgic Cells: Relevance to PD
por: Yoon, Nam Soo, et al.
Publicado: (2010)

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency
por: Ternette, Nicola, et al.
Publicado: (2013)

Studying Acetylation of Aconitase Isozymes by Genetic Code Expansion
por: Araujo, Jessica, et al.
Publicado: (2022)

Parkinsonism mutations in DNAJC6 cause lipid defects and neurodegeneration that are rescued by Synj1
por: Jacquemyn, Julie, et al.
Publicado: (2023)

Near-Infrared 808 nm Light Boosts Complex IV-Dependent Respiration and Rescues a Parkinson-Related pink1 Model
por: Vos, Melissa, et al.
Publicado: (2013)

Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants
por: de Castro, I P, et al.
Publicado: (2013)

Tau association with synaptic vesicles causes presynaptic dysfunction
por: Zhou, Lujia, et al.
Publicado: (2017)

Oxidative Inactivation of Mitochondrial Aconitase Results in Iron and H(2)O(2)-Mediated Neurotoxicity in Rat Primary Mesencephalic Cultures
por: Cantu, David, et al.
Publicado: (2009)

The iron-sensing aconitase B binds its own mRNA to prevent sRNA-induced mRNA cleavage
por: Benjamin, Julie-Anna M., et al.
Publicado: (2014)

Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues
por: Singh, Keshav K, et al.
Publicado: (2006)

Baicalein Attenuates Brain Iron Accumulation through Protecting Aconitase 1 from Oxidative Stress in Rotenone-Induced Parkinson’s Disease in Rats
por: Liu, Run-Zhe, et al.
Publicado: (2022)

Atg1-mediated autophagy suppresses tissue degeneration in pink1/parkin mutants by promoting mitochondrial fission in Drosophila
por: Ma, Peng, et al.
Publicado: (2018)

Drosophila PINK1 and parkin loss-of-function mutants display a range of non-motor Parkinson's disease phenotypes
por: Julienne, Hannah, et al.
Publicado: (2017)

Flavonoid-Deficient Mutants in Grass Pea (Lathyrus sativus L.): Genetic Control, Linkage Relationships, and Mapping with Aconitase and S-Nitrosoglutathione Reductase Isozyme Loci
por: Talukdar, Dibyendu
Publicado: (2012)

Molecular Evolution and Expression Divergence of the Aconitase (ACO) Gene Family in Land Plants
por: Wang, Yi-Ming, et al.
Publicado: (2016)

Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response
por: Kim, Eunah, et al.
Publicado: (2023)

Synaptic Mitochondria in Synaptic Transmission and Organization of Vesicle Pools in Health and Disease
por: Vos, Melissa, et al.
Publicado: (2010)

The Complex I Subunit NDUFA10 Selectively Rescues Drosophila pink1 Mutants through a Mechanism Independent of Mitophagy
por: Pogson, Joe H., et al.
Publicado: (2014)

Retracted: Flavonoid-Deficient Mutants in Grass Pea (Lathyrus sativus L.): Genetic Control, Linkage Relationships, and Mapping with Aconitase and S-Nitrosoglutathione Reductase Isozyme Loci
por: The Scientific World Journal,
Publicado: (2016)

Aconitase B Is Required for Optimal Growth of Xanthomonas campestris pv. vesicatoria in Pepper Plants
por: Kirchberg, Janine, et al.
Publicado: (2012)

Functional characterization of aconitase X as a cis-3-hydroxy-L-proline dehydratase
por: Watanabe, Seiya, et al.
Publicado: (2016)

Nitric Oxide Improves the Tolerance of Pleurotus ostreatus to Heat Stress by Inhibiting Mitochondrial Aconitase
por: Hou, Ludan, et al.
Publicado: (2020)

Transition Zone1 Negatively Regulates Arabidopsis Aluminum Resistance Through Interaction With Aconitases
por: Liu, Jiajia, et al.
Publicado: (2022)

GWAS on multiple traits identifies mitochondrial ACONITASE3 as important for acclimation to submergence stress
por: Meng, Xiangxiang, et al.
Publicado: (2022)

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
por: Morais, Vanessa A, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_9age9phm0enl23u70sggel52aa