Human Germline Antibody Gene Segments Encode Polyspecific Antibodies

Structural flexibility in germline gene-encoded antibodies allows promiscuous binding to diverse antigens. The binding affinity and specificity for a particular epitope typically increase as antibody genes acquire somatic mutations in antigen-stimulated B cells. In this work, we investigated whether...

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Detalles Bibliográficos
Autores principales: Willis, Jordan R., Briney, Bryan S., DeLuca, Samuel L., Crowe, James E., Meiler, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636087/
https://www.ncbi.nlm.nih.gov/pubmed/23637590
http://dx.doi.org/10.1371/journal.pcbi.1003045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636087/
https://www.ncbi.nlm.nih.gov/pubmed/23637590
http://dx.doi.org/10.1371/journal.pcbi.1003045

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