Cargando…

Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKKβ

We recently showed that bitter melon-derived triterpenoids (BMTs) activate AMPK and increase GLUT4 translocation to the plasma membrane in vitro, and improve glucose disposal in insulin resistant models in vivo. Here we interrogated the mechanism by which these novel compounds activate AMPK, a leadi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iseli, Tristan J., Turner, Nigel, Zeng, Xiao-Yi, Cooney, Gregory J., Kraegen, Edward W., Yao, Sheng, Ye, Yang, James, David E., Ye, Ji-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636144/ https://www.ncbi.nlm.nih.gov/pubmed/23638033 http://dx.doi.org/10.1371/journal.pone.0062309

Ejemplares similares

CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle
por: Negoita, Florentina, et al.
Publicado: (2023)

The role of CaMKK2 in Golgi-associated vesicle trafficking
por: Kennedy, Grace, et al.
Publicado: (2023)

Propofol inhibited autophagy through Ca(2+)/CaMKKβ/AMPK/mTOR pathway in OGD/R-induced neuron injury
por: Sun, Bei, et al.
Publicado: (2018)

Hyperbaric oxygen promotes mitophagy by activating CaMKKβ/AMPK signal pathway in rats of neuropathic pain
por: Kun, Liu, et al.
Publicado: (2019)

Dihydromyricetin Ameliorates Inflammation-Induced Insulin Resistance via Phospholipase C-CaMKK-AMPK Signal Pathway
por: Hou, Lianjie, et al.
Publicado: (2021)

Dihydromyricetin resists inflammation‐induced muscle atrophy via ryanodine receptor‐CaMKK‐AMPK signal pathway
por: Hou, Lianjie, et al.
Publicado: (2021)

TRPM7-Mediated Ca(2+) Regulates Mussel Settlement through the CaMKKβ-AMPK-SGF1 Pathway
por: He, Jian, et al.
Publicado: (2023)

Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells
por: Zhao, Fei, et al.
Publicado: (2015)

The red pepper’s spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKKβ
por: Bort, Alicia, et al.
Publicado: (2019)

Myosin-18B Promotes Mechanosensitive CaMKK2-AMPK-VASP Regulation of Contractile Actin Stress Fibers
por: Zhao, Shuangshuang, et al.
Publicado: (2020)

CaMKK2 Suppresses Muscle Regeneration through the Inhibition of Myoblast Proliferation and Differentiation
por: Ye, Cheng, et al.
Publicado: (2016)

uPA Attenuated LPS-induced Inflammatory Osteoclastogenesis through the Plasmin/PAR-1/Ca(2+)/CaMKK/AMPK Axis
por: Kanno, Yosuke, et al.
Publicado: (2016)

Androgen Receptor-CaMKK2 Axis in Prostate Cancer and Bone Microenvironment
por: Dadwal, Ushashi C., et al.
Publicado: (2018)

Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma
por: Tomaszewski, William H., et al.
Publicado: (2022)

Inflammatory mechanisms in post-traumatic osteoarthritis: a role for CaMKK2
por: Riggs, Keegan C., et al.
Publicado: (2023)

Sipjeondaebo-tang Alleviates Oxidative Stress-Mediated Liver Injury through Activation of the CaMKK2-AMPK Signaling Pathway
por: Park, Sang Mi, et al.
Publicado: (2018)

The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways
por: Chen, Xubo, et al.
Publicado: (2017)

Orexin A alleviates neuroinflammation via OXR2/CaMKKβ/AMPK signaling pathway after ICH in mice
por: Li, Tao, et al.
Publicado: (2020)

Hispidulin Enhances TRAIL-Mediated Apoptosis via CaMKKβ/AMPK/USP51 Axis-Mediated Bim Stabilization
por: Woo, Seon Min, et al.
Publicado: (2019)

Oxidative stress induced by hydrogen peroxide promotes glycolysis by activating CaMKK/LKB1/AMPK pathway in broiler breast muscle
por: Chen, Zuodong, et al.
Publicado: (2021)

Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD
por: York, Brian, et al.
Publicado: (2017)

Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer Metastasis
por: Mukherjee, Debarati, et al.
Publicado: (2023)

Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKKβ-Dependent AMPK Activation
por: Li, Chuwen, et al.
Publicado: (2018)

Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/CaMKIV pathway
por: Li, Junhua, et al.
Publicado: (2010)

Impact of Genetic Variation on Human CaMKK2 Regulation by Ca(2+)-Calmodulin and Multisite Phosphorylation
por: O’Brien, Matthew T., et al.
Publicado: (2017)

Enhanced Expression of WD Repeat-Containing Protein 35 via CaMKK/AMPK Activation in Bupivacaine-Treated Neuro2a Cells
por: Huang, Lei, et al.
Publicado: (2014)

Clopidogrel Protects Endothelium by Hindering TNFα-Induced VCAM-1 Expression through CaMKKβ/AMPK/Nrf2 Pathway
por: Yang, Huabing, et al.
Publicado: (2016)

Duck enteritis virus activates CaMKKβ-AMPK to trigger autophagy in duck embryo fibroblast cells via increased cytosolic calcium
por: Yin, Haichang, et al.
Publicado: (2018)

TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway
por: Zhang, Peng, et al.
Publicado: (2017)

CTRP13 attenuates the expression of LN and CAV-1 Induced by high glucose via CaMKKβ/AMPK pathway in rLSECs
por: Zhang, Qi, et al.
Publicado: (2020)

AMPK Alters Detrusor Contractility During Emptying in Normal Bladder and Hypertrophied Bladder with Partial Bladder Outlet Obstruction via CaMKKβ
por: Choi, Bo-Hwa, et al.
Publicado: (2019)

Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance
por: Quiñones, Mar, et al.
Publicado: (2015)

BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes
por: Kim, Hyoung Kyu, et al.
Publicado: (2020)

CaMKK2 facilitates Golgi-associated vesicle trafficking to sustain cancer cell proliferation
por: Stewart, Lorna M., et al.
Publicado: (2021)

Vagal nerve stimulation improves mitochondrial dynamics via an M(3) receptor/CaMKKβ/AMPK pathway in isoproterenol‐induced myocardial ischaemia
por: Xue, Run‐Qing, et al.
Publicado: (2016)

Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy
por: Lim, Ji Hee, et al.
Publicado: (2018)

Isovitexin-Mediated Regulation of Microglial Polarization in Lipopolysaccharide-Induced Neuroinflammation via Activation of the CaMKKβ/AMPK-PGC-1α Signaling Axis
por: Liu, Bingrun, et al.
Publicado: (2019)

L-theanine prevents progression of nonalcoholic hepatic steatosis by regulating hepatocyte lipid metabolic pathways via the CaMKKβ-AMPK signaling pathway
por: Liang, Juanjuan, et al.
Publicado: (2022)

CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer
por: Racioppi, Luigi, et al.
Publicado: (2019)

Data for the co-expression and purification of human recombinant CaMKK2 in complex with calmodulin in Escherichia coli
por: Gerner, Lisa, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rmbs0p6ejei5ch3tiqetnlcopu