Effect of Alanine Replacement of L17 and F19 on the Aggregation and Neurotoxicity of Arctic-Type Aβ(40)

Alzheimer’s disease is the most common form of neurodegenerative disease. Beta-amyloid peptides (Aβ) are responsible for neuronal death both in vitro and in vivo. Previously, L17 and F19 residues were identified as playing key roles in the stabilization of the Aβ(40) conformation and in the reductio...

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Detalles Bibliográficos
Autores principales: Chen, Yi-Ru, Huang, Hsien-bin, Lo, Chi-Jen, Wang, Chih-Ching, Ho, Li-Kang, Liu, Hsin-Tzu, Shiao, Ming-Shi, Lin, Ta-Hsien, Chen, Yi-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636269/
https://www.ncbi.nlm.nih.gov/pubmed/23634215
http://dx.doi.org/10.1371/journal.pone.0061874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636269/
https://www.ncbi.nlm.nih.gov/pubmed/23634215
http://dx.doi.org/10.1371/journal.pone.0061874

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