Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome

Deposition of aggregated amyloid beta (Aβ) is a major hallmark of Alzheimer’s disease (AD)—a common age-related neurodegenerative disorder. Typically, Aβ is generated as a peptide of varying lengths. However, a major fraction of Aβ peptides in the brains of AD patients has undergone posttranslationa...

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Detalles Bibliográficos
Autores principales: De Kimpe, Line, van Haastert, Elise S., Kaminari, Archontia, Zwart, Rob, Rutjes, Helma, Hoozemans, Jeroen J. M., Scheper, Wiep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636379/
https://www.ncbi.nlm.nih.gov/pubmed/22477259
http://dx.doi.org/10.1007/s11357-012-9403-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636379/
https://www.ncbi.nlm.nih.gov/pubmed/22477259
http://dx.doi.org/10.1007/s11357-012-9403-0

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