The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites: Analysis of DmWRNexo activity in vitro

Werner syndrome (WS) is a rare late-onset premature ageing disease showing many of the phenotypes associated with normal ageing, and provides one of the best models for investigating cellular pathways that lead to normal ageing. WS is caused by mutation of WRN, which encodes a multifunctional DNA re...

Descripción completa

Detalles Bibliográficos
Autores principales: Mason, Penelope A., Boubriak, Ivan, Robbins, Timothy, Lasala, Ralph, Saunders, Robert, Cox, Lynne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636389/
https://www.ncbi.nlm.nih.gov/pubmed/22562358
http://dx.doi.org/10.1007/s11357-012-9411-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636389/
https://www.ncbi.nlm.nih.gov/pubmed/22562358
http://dx.doi.org/10.1007/s11357-012-9411-0

Ejemplares similares