Allele-Specific Transcriptional Activity at Type 2 Diabetes–Associated Single Nucleotide Polymorphisms in Regions of Pancreatic Islet Open Chromatin at the JAZF1 Locus

Translation of noncoding common variant association signals into meaningful molecular and biological mechanisms explaining disease susceptibility remains challenging. For the type 2 diabetes association signal in JAZF1 intron 1, we hypothesized that the underlying risk variants have cis-regulatory e...

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Detalles Bibliográficos
Autores principales: Fogarty, Marie P., Panhuis, Tami M., Vadlamudi, Swarooparani, Buchkovich, Martin L., Mohlke, Karen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636602/
https://www.ncbi.nlm.nih.gov/pubmed/23328127
http://dx.doi.org/10.2337/db12-0972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636602/
https://www.ncbi.nlm.nih.gov/pubmed/23328127
http://dx.doi.org/10.2337/db12-0972

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