Neprilysin Deficiency Protects Against Fat-Induced Insulin Secretory Dysfunction by Maintaining Calcium Influx

Neprilysin contributes to free fatty acid (FFA)-induced cellular dysfunction in nonislet tissues in type 2 diabetes. Here, we show for the first time that with prolonged FFA exposure, islet neprilysin is upregulated and this is associated with reduced insulin pre-mRNA and ATP levels, oxidative/nitra...

Descripción completa

Detalles Bibliográficos
Autores principales: Zraika, Sakeneh, Koh, Duk-Su, Barrow, Breanne M., Lu, Bao, Kahn, Steven E., Andrikopoulos, Sofianos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636612/
https://www.ncbi.nlm.nih.gov/pubmed/23328128
http://dx.doi.org/10.2337/db11-1593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636612/
https://www.ncbi.nlm.nih.gov/pubmed/23328128
http://dx.doi.org/10.2337/db11-1593

Ejemplares similares