Tolbutamide Controls Glucagon Release From Mouse Islets Differently Than Glucose: Involvement of K(ATP) Channels From Both α-Cells and δ-Cells

We evaluated the role of ATP-sensitive K(+) (K(ATP)) channels, somatostatin, and Zn(2+) in the control of glucagon secretion from mouse islets. Switching from 1 to 7 mmol/L glucose inhibited glucagon release. Diazoxide did not reverse the glucagonostatic effect of glucose. Tolbutamide decreased gluc...

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Detalles Bibliográficos
Autores principales: Cheng-Xue, Rui, Gómez-Ruiz, Ana, Antoine, Nancy, Noël, Laura A., Chae, Hee-Young, Ravier, Magalie A., Chimienti, Fabrice, Schuit, Frans C., Gilon, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636641/
https://www.ncbi.nlm.nih.gov/pubmed/23382449
http://dx.doi.org/10.2337/db12-0347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636641/
https://www.ncbi.nlm.nih.gov/pubmed/23382449
http://dx.doi.org/10.2337/db12-0347

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