Cargando…

Tolbutamide Controls Glucagon Release From Mouse Islets Differently Than Glucose: Involvement of K(ATP) Channels From Both α-Cells and δ-Cells

We evaluated the role of ATP-sensitive K(+) (K(ATP)) channels, somatostatin, and Zn(2+) in the control of glucagon secretion from mouse islets. Switching from 1 to 7 mmol/L glucose inhibited glucagon release. Diazoxide did not reverse the glucagonostatic effect of glucose. Tolbutamide decreased gluc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng-Xue, Rui, Gómez-Ruiz, Ana, Antoine, Nancy, Noël, Laura A., Chae, Hee-Young, Ravier, Magalie A., Chimienti, Fabrice, Schuit, Frans C., Gilon, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636641/ https://www.ncbi.nlm.nih.gov/pubmed/23382449 http://dx.doi.org/10.2337/db12-0347

Ejemplares similares

Mechanisms of Control of the Free Ca(2+) Concentration in the Endoplasmic Reticulum of Mouse Pancreatic β-Cells: Interplay With Cell Metabolism and [Ca(2+)](c) and Role of SERCA2b and SERCA3
por: Ravier, Magalie A., et al.
Publicado: (2011)

Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic β cells
por: Tarasov, Andrei I., et al.
Publicado: (2012)

Zinc transporters and their role in the pancreatic β‐cell
por: Lemaire, Katleen, et al.
Publicado: (2012)

A K(ATP) Channel-Dependent Pathway within α Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans
por: MacDonald, Patrick E, et al.
Publicado: (2007)

The Mitochondrial Ca(2+) Uniporter MCU Is Essential for Glucose-Induced ATP Increases in Pancreatic β-Cells
por: Tarasov, Andrei I., et al.
Publicado: (2012)

Effect of Temperature on Tolbutamide Binding to Glycated Serum Albumin
por: Szkudlarek, Agnieszka, et al.
Publicado: (2017)

K(ATP) channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca(2+)](c) rise and an indirect inhibition mediated by somatostatin
por: Singh, Bilal, et al.
Publicado: (2021)

The potential for interaction of tolbutamide with pomegranate juice against diabetic induced complications in rats
por: Chakraborty, Manodeep, et al.
Publicado: (2017)

In Vitro Investigation of the Interaction of Tolbutamide and Losartan with Human Serum Albumin in Hyperglycemia States
por: Szkudlarek, Agnieszka, et al.
Publicado: (2017)

How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress?
por: Lemaire, Katleen, et al.
Publicado: (2017)

Selective Somatostatin 5 (SST5) and Somatostatin 2 (SST2) Nonpeptide Agonists Potently Suppress Glucose- and Tolbutamide-Stimulated Dynamic Insulin Secretion From Isolated Human Islets
por: Rico, Elizabeth, et al.
Publicado: (2021)

δ-Cells: The Neighborhood Watch in the Islet Community
por: Gao, Rui, et al.
Publicado: (2021)

Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats
por: Sreemantula, Satyanarayana, et al.
Publicado: (2005)

Evaluation of CYP2C9 Activity in Rats: Use of Tolbutamide Alone and in Combined with Bupropion
por: Qiu, Xiangjun, et al.
Publicado: (2014)

Incretin concept revised: The origin of the insulinotropic function of glucagon‐like peptide‐1 – the gut, the islets or both?
por: Yabe, Daisuke, et al.
Publicado: (2017)

Andrographis paniculata Extract and Andrographolide Modulate the Hepatic Drug Metabolism System and Plasma Tolbutamide Concentrations in Rats
por: Chen, Haw-Wen, et al.
Publicado: (2013)

Leucine suppresses glucagon secretion from pancreatic islets by directly modulating α-cell cAMP
por: Knuth, Emily R., et al.
Publicado: (2023)

Abnormal regulation of glucagon secretion by human islet alpha cells in the absence of beta cells
por: Liu, Wei, et al.
Publicado: (2019)

Glucose Decouples Intracellular Ca(2+) Activity from Glucagon Secretion in Mouse Pancreatic Islet Alpha-Cells
por: Le Marchand, Sylvain J., et al.
Publicado: (2012)

GPR142 prompts glucagon-like Peptide-1 release from islets to improve β cell function
por: Lin, Hua V., et al.
Publicado: (2018)

Somatostatin Secreted by Islet δ-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function
por: Hauge-Evans, Astrid C., et al.
Publicado: (2009)

A microfluidic system for monitoring glucagon secretion from human pancreatic islets of Langerhans
por: Eaton, Wesley J., et al.
Publicado: (2021)

ULTRASTRUCTURE OF THE A-CELLS OF CAT ISLETS OF LANGERHANS FOLLOWING SYMPATHETIC STIMULATION OF GLUCAGON SECRETION
por: Esterhuizen, A. C., et al.
Publicado: (1970)

Normal Pregnancy-Induced Islet Beta Cell Proliferation in Mouse Models That Are Deficient in Serotonin-Signaling
por: Goyvaerts, Lotte, et al.
Publicado: (2022)

The diabetes gene Hhex maintains δ-cell differentiation and islet function
por: Zhang, Jia, et al.
Publicado: (2014)

Mechanisms of Beta-Cell Apoptosis in Type 2 Diabetes-Prone Situations and Potential Protection by GLP-1-Based Therapies
por: Costes, Safia, et al.
Publicado: (2021)

Metabolic Stress Impairs Pericyte Response to Optogenetic Stimulation in Pancreatic Islets
por: Michau, Aurélien, et al.
Publicado: (2022)

Intra-islet glucagon secretion and action in the regulation of glucose homeostasis
por: Wang, Qinghua, et al.
Publicado: (2013)

Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon
por: Peschke, Elmar, et al.
Publicado: (2013)

In vivo studies of glucagon secretion by human islets transplanted in mice
por: Tellez, Krissie, et al.
Publicado: (2020)

Small molecule glucagon release inhibitors with activity in human islets
por: Kalwat, Michael A., et al.
Publicado: (2023)

Small Mouse Islets Are Deficient in Glucagon-Producing Alpha Cells but Rich in Somatostatin-Secreting Delta Cells
por: Lau, Joey, et al.
Publicado: (2016)

Physiologically Based Pharmacokinetic Modelling of Cytochrome P450 2C9-Related Tolbutamide Drug Interactions with Sulfaphenazole and Tasisulam
por: Perkins, Everett J., et al.
Publicado: (2017)

Immunohistochemical localization of glucagon and pancreatic polypeptide on rat endocrine pancreas: coexistence in rat islet cells
por: Huang, Y.H., et al.
Publicado: (2009)

Glucagon-Producing Cell Expansion in Wistar Rats. Changes to Islet Architecture After Sleeve Gastrectomy
por: Bancalero-delosReyes, José, et al.
Publicado: (2021)

Submembrane ATP and Ca(2+) kinetics in α-cells: unexpected signaling for glucagon secretion
por: Li, Jia, et al.
Publicado: (2015)

Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in α-Cells Inhibits Glucagon Secretion From Human Islets
por: Ramracheya, Reshma, et al.
Publicado: (2010)

Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells
por: Emfinger, Christopher H., et al.
Publicado: (2017)

Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon
por: Cabrera, Over, et al.
Publicado: (2021)

Islet α-, β-, and δ-Cell Development Is Controlled by the Ldb1 Coregulator, Acting Primarily With the Islet-1 Transcription Factor
por: Hunter, Chad S., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_t22mfqr35ttucs8k8pj7o2n7fa